AMPK Metabolic Activator / 활력 노화방지 Life Extension

 

AMPK Activator / Life Extension

 

Emulates Cell Energizing Effects of  Caloric Restriction

 활력 , 노화방지 및 뱃살지방 연소 

 

Description

• AMPK Activator
• 30 vegetarian capsules

 

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AMPK is an enzyme that serves as the body's master regulating switch.  AMPK 는 신진대사 를 조절하는 스위치 역활의 효소 입니다   It inhibits multiple damaging factors by revitalizing aging cells.1   즉 노화세포 의  여러 손상요인 을 억제 하고 활성화 합니다.   Found in every cell,2,3 AMPK promotes longevity factors that have been shown to extend life span in numerous organisms.1,4 Increasing AMPK signaling "turns off" many damaging effects of aging, thus enabling cells to return to their youthful vitality.5 Life Extension® scientists have compiled years of research to create AMPK Activator, a specialized dual-extract formulation that supports AMPK activation for health optimization. This natural formula supports AMPK enzymatic activities required to safely support a more youthful cellular environment.     다년간 연구결과 AMPK 의 활성화 는 보다 젊은세포 유지 ( 노화방지) 환경에 도움을 줍니다   최근 노화방지 작용 으로 갑자기 주목받는 당뇨약  메트포르민 (metformin) 과 AMPK 의 관계   메트포르민 ( metformin) 의 새로운 기전으로 간과 근육에서 AMPK (AMP-activated protein kinase)를 활성화시킨다는 것이 밝혀졌습니다.   그에 따르면 근육에서 AMPK를 활성화 함으로써 근육의 당 흡수를 증가시킵니다. 간에서는 AMPK 를 활성화 함으로써 지방 합성에 관련된 효소인 ACC의 활성이나 SREBP-1의 발현을 감소시키고 당신생을 억제하는 한편 지방 합성에 관여하는 효소들을 저하시켜 지방산의 산화를 증가시키고 VLDL의 합성을 억제하여 궁극적으로 지방간을 줄여주고 간의 인슐린 민감도를 높여줍니다. Importance of AMPK Greater AMPK (adenosine monophosphate-activated protein kinase) activation has been shown to help target damaging factors of aging.5 Studies show increased AMPK activity supports reduced fat storage,6 new mitochondria production,7 and the promotion of healthy blood glucose and lipids already within normal range.4 Gynostemma Pentaphyllum An extract of the plant Gynostemma pentaphyllum was traditionally used in Asian medicine to promote longevity and scientists now know why—G. pentaphyllum promotes AMPK activation.8-10 In one of many studies showing a wide variety of benefits, researchers documented a 1-inch reduction in abdominal circumference in overweight individuals who took 450 mg daily of G. pentaphyllum extract for 12 weeks.11 Trans-Tiliroside Trans-tiliroside, extracted from plants such as rose hips, also boosts AMPK activation, but triggers different down­stream metabolic benefits than G. pentaphyllum.12-14  Among its many benefits, a low equivalent dose of 56 mg daily trans-tiliroside has been shown by researchers in preclinical studies to promote healthy blood glucose levels and body weight already within normal range.15 Anti-Aging Discovery that Cannot be Overlooked Scientists uncovered the cell-energizing effect of AMPK in the 1970s. Since then, an exponential volume of data (over 7,500 published studies) documents the critical role that activated AMPK plays in maintaining life-sustaining cellular functions. Those seeking to meaningfully extend their healthy life span should ensure they optimally activate their cellular AMPK. The reason this is so important is that in response to aging, excess calorie consumption, and/or low levels of physical activity, AMPK activity markedly declines. A targeted way of reversing cellular depletion of this critical enzyme is to take the new AMPK Activator formula that comprises a dual-extract, plant-based formulation.  This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

References 1. J Mol Med (Berl). 2011 Jul;89(7):667-76. 2. J Proteome Res. 2011 Apr 1;10(4):1690-7. 3. Circ Res. 2007 Feb 16;100(3):328-41. 4. Physiol Rev. 2009 89:1025–78. 5. Age (Dordr). 2014 Apr;36(2):641-63. 6. Clin Sci (Lond). 2013 Apr;124(8):491-507. 7. Proc Natl Acad Sci USA. 2002 Dec 10;99 (25):15983-7. 8. Bioorg Med Chem. 2011 Nov 1;19(21):6254-60. 9. Carbohydr Polym. 2012 Jul 1;89(3):942-7. 10. Biotechnol Lett. 2012 Sep;34(9):1607-16. 11. Obesity (Silver Spring). 2014 Jan;22(1):63-71. 12. Diabetes Res Clin Pract. 2011 May;92(2):e41-6. 13. Prev Nutr Food Sci. 2013 Jun;18(2):85-91. 14. J Nutr Biochem. 2012 Jul;23(7):768-76. 15. Bioorg Med Chem Lett. 2007;17(11):3059-64.

 

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자료제공 : 미국직송 건강식품 아이헬스라이프 www.iHealthLife.com

 

 

Metformin Anti-Aging Study on Humans Wins FDA Approval Headline News Describes Multiple Benefits

Dear Supporter, In case you missed the headline health news last week, the mainstream media has caught up to the potential life-extending health benefits of metformin — something our long-term supporters discovered long ago. What caught the media's attention is the FDA's approval of a large-scale human study to see if metformin can protect against the multiple diseases of aging. Prominent headlines proclaimed: "New Anti-Aging Drug Could Extend Human Life Span to 120 Years" This headline is inaccurate. For one, metformin is not a new drug. It was approved in England in 1957 and made available to type II diabetics around the world shortly thereafter. It took the FDA a staggering 37 years to approve it in the United States. Here are some accurate quotes from worldwide news sources: "Although it might seem like science fiction, researchers have already proven that the diabetes drug metformin extends the life of animals, and the Food and Drug Administration in the US has now given the go ahead for a trial to see if the same effects can be replicated in humans." "I have been doing research into aging for 25 years and the idea that we would be talking about a clinical trial in humans for an anti-aging drug would have been thought inconceivable…20 years ago aging was a biological mystery. Now we are starting to understand what is going on." "Scientists think the best candidate for an anti-aging drug is metformin, the world's most widely used diabetes drug which costs just 10p a day. Metformin increases the number of oxygen molecules released into a cell, which appears to boost robustness and longevity." "If we can slow aging in humans, even by just a little bit, it would be monumental. People could be older, and feel young." "This would be the most important medical intervention in the modern era, an ability to slow aging." Dr Simon Melov of the Buck Institute for Research on Aging added: "You're talking about developing a therapy for a biological phenomenon which is universal and gives rise to all of these diseases. And if you've got a therapy for this thing, these diseases just go away." Life Extension® Has Championed Metformin for 20 Years Life Extension Magazine® listed metformin as one of many important offshore medications way back in 1995. And now, 20 years later, even the FDA concurs that metformin has potential to delay the onset of degenerative disease. But contrary to all the news headlines, metformin cannot enable humans to live to 120 years of age all by itself. What it may do is allow humans to age better today — thereby staving off degenerative disease long enough for age-reversal breakthroughs to become clinically available. But How Does Metformin Work? Metformin's primary mechanism is to enhance the activity of an enzyme found within our cells called adenosine monophosphate-activated protein kinase — or AMPK for short. AMPK activation helps mimic the beneficial effects of calorie restriction, the best documented method of slowing and reversing biomarkers of human aging.  메트포르민 의 기본역활은 효소인 AMPK 를 활성화 하는것 입니다   Life Extension has long endorsed AMPK activation as a method of slowing biological aging. We advocate that our supporters utilize some proven method to increase their cellular AMPK activity — which could add substantial healthy years to the average life span. It is worth noting that if you're presently taking 1,000 to 2,550 mg of metformin daily, you don't have to do anything — simply enjoy this drug's anti-aging benefits. But if you cannot acquire a prescription for metformin, or cannot tolerate it due to digestive issues, there are nutrient formulas that have been shown to significantly boost AMPK activity. Boost AMPK Activation Today 만약 당신이 당뇨약 메트포르민 을 처방받아 매일 1,000 ~2550mg 씩 섭취 하신다면 노화예방을 위해 추가로 하실일은 없습니다 만 그렇치 않다면 그대신 지금 바로 AMPK Activator 를 드시기 바랍니다 We here at Life Extension do not want you to age prematurely, waiting years for the results of the new FDA-approved human study. That's why we recommend you initiate steps now to boost healthy AMPK activity today. Below my signature are links to three of the many articles appearing around the world about the first clinical trial to see if metformin can slow aging and enable people to live longer. To learn more about AMPK activation, please visit www.LifeExtension.com For longer life,